• info@icbcongress.com
• English
• Persian

• Login

Create Free Account

INTERNATIONAL CONGRESS OF

PharmacoGenetics

• Utilizing Personalized Medicine to Diagnose and Treat Helicobacter pylori: Targeted Prevention and Treatment Strategies

• Armin Kalanaki,^1,* Nariman Jafari,² Yasna Azizpour,³
  1. Department of Biology, SR.C., Islamic Azad University, Tehran, Iran.
  2. Department of Biology, SR.C., Islamic Azad University, Tehran, Iran.
  3. Department of Biology, SR.C., Islamic Azad University, Tehran, Iran.
  
  
  
• Introduction: Helicobacter pylori (H. pylori) is a Gram-negative bacterium implicated in the pathogenesis of peptic ulcer disease, gastric cancer, and mucosa-associated lymphoid tissue lymphoma. Eradication of H. pylori can reduce the recurrence rate of peptic ulcers and lower the risk of gastric malignancies. However, the standard triple therapy, consisting of a proton pump inhibitor (PPI), clarithromycin, and either amoxicillin or metronidazole, has gradually lost its efficacy in recent years. This trend is primarily associated with the increasing prevalence of antibiotic resistance. Personalized medicine provides a framework for achieving precise diagnosis and delivering treatment plans that are specifically tailored to the individual’s unique clinical and genetic characteristics. Utilizing approaches such as antibiotic susceptibility testing, it is possible to customize antibiotic therapy to effectively manage infections on a patient-specific basis. Furthermore, eradication rates can be enhanced through pharmacogenomic-guided therapy based on the patient’s CYP2C19 genotype. This study investigates the enhancement of diagnostic accuracy and therapeutic efficacy through personalized approaches in H. pylori infection. In addition, the study aims to explore accurate and rapid diagnostic approaches for H. pylori and to assess personalized therapeutic strategies for its effective management.
• Methods: To address the objectives of this study, we searched databases such as PubMed and Google Scholar using terms related to Helicobacter pylori and Personalized Medicine to find articles relevant to the research topic.
• Results: Personalized medicine has a significant role in the treatment of H. pylori. Currently, through precise bacterial identification and careful evaluation of the patient's medical history, symptoms, and laboratory findings, it is possible to recommend patient-specific medication.
• Conclusion: H. pylori significantly contributes to the development of peptic ulcers and gastric malignancies, underscoring the importance of exploring personalized medicine approaches in its detection and clinical management. The role of personalized medicine in the treatment of various diseases, including H. pylori infection, has gained considerable attention, and research continues to focus on enhancing its therapeutic efficacy. Therefore, the expanded use and development of personalized medicine in the future is expected to play a pivotal role in the eradication of many diseases, particularly H. pylori infection.
• Keywords: Personalized medicine, Helicobacter pylori, Antibiotic resistance