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INTERNATIONAL CONGRESS OF

PharmacoGenetics

• pharmacogenetics in veterinary medicine

• Mehrnaz Bavafa toosi,^1,* Matineh Delrobaei,² Zahra Bakhtiari,³
  1. Ferdowsi University of Mashhad
  2. Ferdowsi University of Mashhad
  3. Ferdowsi University of Mashhad
  
  
  
• Introduction: Pharmacogenetics focuses on how an individual's genotype or genetic makeup affects the pharmacokinetics and pharmacodynamics of therapeutic agents, whose knowledge can positively impact the drug development process. Pharmacogenetics studies specific genes that remarkably influence the response to a drug. Like humans, animal patients respond to drugs very differently. Changes in drug response often cause problems in treatment. One of the key factors contributing to variability in drug responses is genetic factors. Variety in drug response often causes problems in the treatment because it can lead to efficacy and sometimes serious adverse drug reactions. One of the important factors contributing to variability in drug responses is genetic factors. Therefore; pharmacogenetics can be helpful and effective. This article aims to review veterinary pharmacogenetic research.
• Methods: To review studies focused on this topic, Google Scholar, PubMed, and Scopus databases with keywords "pharmacogenetics " and " veterinary medicine " were searched between 2010 and 2024 for related articles.
• Results: polymorphisms in animal cause differences in response to drug therapy. For example, in some dogs (especially collies) ABCB1 gene polymorphism causes fatal reactions to many p-glycoprotein (p-gp) substrates. In dogs and cats with ABCB1 mutation p-gp substrates are at considerably higher concentrations. In cattle, there have been data on ABCG2 polymorphism that affects the treatment of mastitis and the residues of drugs in dairy milk. Genetic variation causes variation in drug absorption, distribution, metabolism, and excretion in each individual. these pharmacokinetic processes are effective in drug efficacy and toxicity. Investigations in this field have been conducted on antiparasitic drugs, anti-inflammatory drugs, opioids, and anesthetic agents. Most of these drugs' lethal toxicosis is associated with their administration. mutations in the genes regulating the drug metabolism.
• Conclusion: pharmacogenetic research can help identify drug target polymorphisms and also discover new drug targets. using pharmacogenetics approaches to optimal drug selection and cause a significant increase in drug efficacy. however, more research and investigations are needed in pharmacogenetics in veterinary medicine.
• Keywords: pharmacogenetics- veterinary- medicine