INTERNATIONAL CONGRESS OF
PharmacoGenetics
Cancer treatment with the help of exosomes
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Hossein ameri shahrabi,1,*
1. Azad University
- Introduction: The role of exosomes in tumor growth and development has been proven; So that it has been reported as one of the factors in the growth and spread of cancers. Breast cancer is one of the most common types of cancer and one of the causes of cancer-related deaths worldwide. Texosomes can be used as a drug carrier to inhibit cancer.
- Methods: In this study, after separating the exosomes from the patient's serum and determining their nature and size by scanning electron microscopy and transferring Cytolysin A into the exosomes, the effect of Cytolysin A on cancer cells was investigated using flow cytometry. The expression of Bax and Bcl-2 genes in fibroblast cells after treatment with exosome, toxin and exotoxin was investigated using real-time PCR method.
- Results: Effects of Bacterial Toxin Treatment on Induction of Apoptosis or Programmed Cell Death in Cancer Cells Cells were treated with bacterial toxin loaded in exosomes and killed.
- Conclusion: With the help of exosomes, drug or toxin can be carried in it and attack the target cell and destroy it.
- Keywords: Cancer, exosome, extracellular vesicles
